The Asia-Pacific region has problems related to both sanitation and wastewater management, having a large proportion of its population without access to basic sanitation, and pollution worsening in the rivers, lakes and coastal waters of a great majority of countries, which is particularly threatening the sustainable and healthy development of their urban economy. The present report reviews the current situation of sanitation and wastewater management in the Asia-Pacific region, and highlights the challenges faced in both urban and rural contexts. Concrete examples of how administration, utilities and operators, and civil society organizations are responding to the challenges in the following areas are introduced: sanitation and wastewater management, including off-site/on-site sanitation and septage management, human resource development, institutional and regulatory frameworks, and circular economy (wastewater reuse and sludge recycling). This report emphasizes on the importance of partnerships to enable the sharing of knowledge, successful experiences and good practices in sanitation and wastewater management, which is needed to achieve all the tasks required to mainstream wastewater management. Accordingly this report concludes that, partnerships, existing ones for achieving the SDG sanitation targets, and new ones, such as the Asia Wastewater Management Partnership (AWaP) proposed by Japan, should be encouraged.